Science, Technology and Innovation (STI) are key drivers of economic growth and sustainable development in LDCs and SIDS. However, many of these countries face challenges in harnessing the power of STI to drive economic growth and sustainable development in part due to cost constraints, infrastructure deficiencies, geographical insularity, fragmentation and limited knowledge transfer. Addressing these gaps requires efforts at all levels to assist countries to, inter alia, i) Prioritize investments in resilience and research and development; ii) Promote regional cooperation and coordination and strengthen regional research institutions’ technical and institutional capacity through inter alia joint research initiatives, and knowledge sharing; and iii) Effectively mobilize national science and engineering capacity for mission-oriented research to solve specific national/regional problems. This project will support three Lusophone SIDS (Cabo Verde, Guinea-Bissau, and São Tomé and Príncipe) to strengthen their capacity to develop, deploy, and expand their use of STI in the context of the SDGs and particularly for building ocean knowledge and coastal resilience. Recommendations from the project will be piloted on UNESCO designated sites and through relevant multistakeholder networks to amplify project impact at all levels. The Project’s objectives are to strengthen the capacity of government officials and other stakeholders in targeted Small Island Developing States to utilize science, technology and innovation effectively for advancing climate resilience and nature-based solutions in alignment with the Sustainable Development Goals. The project will be jointly implemented by UNDESA, UNECA and UNESCO.